COLLIV

Descrição

Indicações
Doença hepática gordurosa metabólica (DHGM);
Reduz gordura visceral;
Manejo de comorbidades;

referencias:
Material do Fornecedor. 2023.
2. Ministério da saúde. Acesso em: https://www.gov.br/saude/ptbr/
assuntos/saude-de-a-a-z/e/esteatose-hepatica.
3. Wong SK, Chin K-Y, Suhaimi FH, Ahmad F, Ima-Nirwana S. Vitamin E As a
Potential Interventional Treatment for Metabolic Syndrome: Evidence from
Animal and Human Studies. Frontiers in Pharmacology. 8(444) (2017).
4. Azlina, M. N., Nafeeza, M. I., & Khalid, B. A. K. (2005). A comparison between
tocopherol and tocotrienol effects on gastric parameters in rats exposed to
stress. Asia Pacific journal of clinical nutrition, 14(4), 358.
5. Baliarsingh, S., Beg, Z. H., & Ahmad, J. (2005). T . Atherosclerosis, 182(2), 367-
374.
6. Budin, S. B., Othman, F., Louis, S. R., Bakar, M. A., Das, S., & Mohamed, J.
(2009). The effects of palm oil tocotrienol-rich fraction supplementation on
biochemical parameters, oxidative stress and the vascular wall of streptozotocininduced
diabetic rats. Clinics, 64(3), 235-244.
7. Chin, S. F., Ibahim, J., Makpol, S., Hamid, N. A. A., Latiff, A. A., Zakaria, Z., &
Ngah, W. Z. W. (2011). Tocotrienol rich fraction supplementation improved lipid
profile and oxidative status in healthy older adults: A randomized controlled
study. Nutrition & metabolism, 8(1), 42.
8. Chin, S. F., Hamid, N. A. A., Latiff, A. A., Zakaria, Z., Mazlan, M., Yusof, Y. A.
M., & Ngah, W. Z. W. (2008). Reduction of DNA damage in older healthy adults
by Tri E® Tocotrienol supplementation. Nutrition, 24(1), 1-10.
9. Fang, F., Kang, Z., & Wong, C. (2010). Vitamin E tocotrienols improve insulin
sensitivity through activating peroxisome proliferator-activated receptors.
Molecular nutrition & food research, 54(3), 345-352.
10. Gwee Sian Khee, S., Yusof, M., Anum, Y., & Makpol, S. (2014). Expression of
senescence-associated microRNAs and target genes in cellular aging and
modulation by tocotrienol-rich fraction. Oxidative medicine and cellular
longevity, 2014.
11. Muto, C., Yachi, R., Aoki, Y., Koike, T., Igarashi, O., & Kiyose, C. (2012).
Gamma-tocotrienol reduces the triacylglycerol level in rat primary hepatocytes
through regulation of fatty acid metabolism. Journal of clinical biochemistry and
nutrition, 12-97.
12. Qureshi, A. A., Sami, S. A., Salser, W. A., & Khan, F. A. (2002). Dose-dependent
suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran
in hypercholesterolemic humans. Atherosclerosis, 161(1), 199-207.
13. Zaiden, N., WN, Y., Ong, S., VH, T., Nesaretnam, K., & Shiba, S. (2010). Gamma
delta tocotrienols reduce hepatic triglyceride synthesis and VLDL secretion.
Journal of atherosclerosis and thrombosis, 1008090267-1008090267.
14. Zhao, L., Kang, I., Fang, X., Wang, W., Lee, M. A., Hollins, R. R., & Chung, S.
(2015). Gamma-tocotrienol attenuates high-fat diet-induced obesity and insulin
resistance by inhibiting adipose inflammation and M1 macrophage recruitment.
International Journal of Obesity, 39(3), 438-446.
15. Nair A.B. e S.A. Jacob. simple practice guide for dose conversion between
animals and human. Journal of basic and clinical pharmacy, v. 7, n. 2, p. 27,
2016.
16. Reagan-Shaw S., M. Nihal, N. Ahmad. Dose translation from animal to human
studies revisited. The FASEB journal, v. 22, n. 3, 2008.
17. Peh HY, Tan WS, Liao W, Wong WS. Vitamin E therapy beyond cancer:
Tocopherol versus tocotrienol. Pharmacol Ther. 162 (2016), p.152-69.
18. Wong SK, Chin K-Y, Suhaimi FH, Ahmad F, Ima-Nirwana S. Vitamin E As a
Potential Interventional Treatment for Metabolic Syndrome: Evidence from
Animal and Human Studies. Frontiers in Pharmacology. 8(444) (2017).
19. Sen CK, Khanna S, Rink C, Roy S. Tocotrienols: the emerging face of natural
vitamin E. Vitam Horm. 76 (2017) p.203-61.
20. Fernandes NV, Yeganehjoo H, Katuru R, DeBose-Boyd RA, Morris LL, Michon R,
et al. Geranylgeraniol suppresses the viability of human DU145 prostate
carcinoma cells and the level of HMG CoA reductase. Exp Biol Med (Maywood).
238(11) (2013), 1265-74.
21. Madan KA, Devaki T. Geraniol, a component of plant essential oils-a review of
its pharmacological activities. International Journal of Pharmacy and
Pharmaceutical Sciences. 7(4) (2015), p.67-70.
22. Siddiqui S, Khan MR, Siddiqui WA. Comparative hypoglycemicand
nephroprotective effects of tocotrienol rich fraction (TRF) frompalm oil and rice
bran oil against hyperglycemia induced nephropathy in type 1 diabetic rats.
Chem Biol Interact. 188 (2010), p.651–658.
23. Chisté RC, Mercadante AZ, Gomes A, Fernandes E, Lima JLFdC, Bragagnolo N.
In vitro scavenging capacity of annatto seed extracts against reactive oxygen
and nitrogen species. Food chemistry. 127 (2) (2011) p.419-26.
24. Marcuzzi A, Pontillo A, Leo LD, Tommasini A, Decorti G, Not T, et al. Natural
Isoprenoids are Able to Reduce Inflammation in a Mouse Model of Mevalonate
Kinase Deficiency. Pediatric Research. 64 (2008), 177.
25. Magosso, Enrico, et al. "Tocotrienols for normalisation of hepatic echogenic
response in nonalcoholic fatty liver: a randomised placebo-controlled clinical
trial." Nutrition journal 12.1 (2013): 1-8.
26. S. Baliarsingh, Z.H. Beg, J. Ahmad, The therapeutic impacts of tocotrienols in
type 2 diabetic patients with hyperlipidemia, Atherosclerosis, Vol. 182(2), 2005,
p. 367-374.